CKAP5

CKAP5
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	4QMI, 4QMJ
Tanımlayıcılar
Başka adlar	CKAP5, CHTOG, MSPS, TOG, TOGp, ch-TOG, hücre iskeleti ilişkili protein 5
Dış kimlikler	OMIM: 611142 MGI: 1923036 HomoloGene: 8844 GeneCards: CKAP5
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	46,846,308 bç
RNA ekspresyonu deseni
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• GO:0001948, GO:0016582 protein bağlanması; • cadherin binding; • microtubule plus-end binding;
Hücresel bileşeni	• sitoplazma; • Sitozol; • sentrozom; • spindle pole; • membrane; • microtubule cytoskeleton; • gamma-tubulin complex; • microtubule organizing center; • microtubule plus-end; • Hücre iskeleti; • Sentromer; • Kinetokor; • kromozom; • İğ iplikleri; • Çekirdekçik; • Hücre zarı; • GO:0009327 protein-containing complex;
Biyolojik süreci	• RNA transport; • establishment or maintenance of microtubule cytoskeleton polarity; • Hücre bölünmesi; • GO:0043146 spindle organization; • G2/M transition of mitotic cell cycle; • Hücre döngüsü; • sister chromatid cohesion; • centrosome cycle; • microtubule polymerization; • centrosome duplication; • ciliary basal body-plasma membrane docking; • regulation of G2/M transition of mitotic cell cycle; • microtubule depolymerization;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	9793
	75786
	ENSG00000175216
	ENSMUSG00000040549
	Q14008
	A2AGT5
	NM_014756; NM_001008938
	NM_001165989; NM_029437
	NP_001008938; NP_055571
	NP_001159461; NP_083713
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

Hücre iskeletine bağlı protein 5, insanlarda CKAP5 geni tarafından kodlanan mikrotübüle bağlı bir proteindir.^[4]^[5]^[6] Xenopus'un XMAP215 proteininin^[7] homologudur ve ch-Tog olarak da bilinir.

Bunun, en az iki farklı rollere sahiptir iğ ipliği oluşumunda en az iki ayrı rolü vardır: MCAK (KIF2C) aracılığıyla depolimerizasyondan kinetokor mikrotübüllerini korur ve MCAK etkinliğinden bağımsız bir işlev olan sentrozomal mikrotübül birleştiriminde cH-Tog önemli bir rol oynar.^[8]

Etkileşimler

CKAP5'in TACC1 ile etkileşime girdiği gösterilmiştir.^[9]^[10]

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175216 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1). Jul 1995. ss. 37-43.
^ "Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors". Eur. J. Biochem. 234 (2). Feb 1996. ss. 406-13.
^ "Entrez Gene: CKAP5 cytoskeleton associated protein 5". 5 Aralık 2010 tarihinde kaynağından arşivlendi.
^ "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Mol. Biol. Cell. 15 (4). 2004. ss. 1580-90.
^ "MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics". Mol. Cell. Biol. 28 (23). 2008. ss. 7199-211.
^ "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50). Nov 2003. ss. 8102-16.
^ "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1). Apr 2002. ss. 195-200.

Dış bağlantılar

İnsan CKAP5 30 Aralık 2019 tarihinde Wayback Machine sitesinde arşivlendi. genomu yerleşimi ve CKAP5 geni ayrıntıları UCSC Genom Tarayıcısında.

Konuyla ilgili yayınlar

Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW (2007). "Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans". J. Cell Sci. 120 (Pt 7). ss. 1278-87. doi:10.1242/jcs.000604. PMID 17376965.
Kosturko LD, Maggipinto MJ, D'Sa C, Carson JH, Barbarese E (2005). "The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2". Mol. Biol. Cell. 16 (4). ss. 1938-47. doi:10.1091/mbc.E04-08-0709. PMC 1073673 $2. PMID 15703215.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33). ss. 12130-5. doi:10.1073/pnas.0404720101. PMC 514446 $2. PMID 15302935.
Cassimeris L, Morabito J (2004). "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Mol. Biol. Cell. 15 (4). ss. 1580-90. doi:10.1091/mbc.E03-07-0544. PMC 379257 $2. PMID 14718566.
Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50). ss. 8102-16. doi:10.1038/sj.onc.1206972. PMID 14603251.
Gergely F, Draviam VM, Raff JW (2003). "The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells". Genes Dev. 17 (3). ss. 336-41. doi:10.1101/gad.245603. PMC 195983 $2. PMID 12569123.
Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11). ss. 1773-84. doi:10.1101/gr.406902. PMC 187542 $2. PMID 12421765.
Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1). ss. 195-200. doi:10.1042/0264-6021.3630195. PMC 1222467 $2. PMID 11903063.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9). ss. 791-806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nakamura S, Grigoriev I, Nogi T, Hamaji T, Cassimeris L, Mimori-Kiyosue Y (2012). "Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells". PLoS ONE. 7 (12). ss. e51442. doi:10.1371/journal.pone.0051442. PMC 3520847 $2. PMID 23251535.
Zanic M, Widlund PO, Hyman AA, Howard J (2013). "Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels". Nat. Cell Biol. 15 (6). ss. 688-93. doi:10.1038/ncb2744. PMID 23666085.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175216 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7788527-4] "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1). Jul 1995. ss. 37-43.

[pmid8536682-5] "Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors". Eur. J. Biochem. 234 (2). Feb 1996. ss. 406-13.

[entrez-6] "Entrez Gene: CKAP5 cytoskeleton associated protein 5". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

[7] "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly". Mol. Biol. Cell. 15 (4). 2004. ss. 1580-90.

[8] "MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics". Mol. Cell. Biol. 28 (23). 2008. ss. 7199-211.

[pmid14603251-9] "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50). Nov 2003. ss. 8102-16.

[pmid11903063-10] "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1). Apr 2002. ss. 195-200.

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